Adenomyosis
Conditions
Interventions
HIFU combined with GnRH-a Group:HIFU combined with GnRH-a Treatment
GnRH-a Group:GnRH-a treat alone
Sponsors
Xiangya Third Hospital of Central South University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients with clear diagnosis of adenomyosis have treatment indications and fertility requirements (1) The uterus was enlarged and the thickness of myometrium was more than 3 cm (no more than the size of uterus in 3-month pregnancy); (2) Menorrhagia; (3) They have dysmenorrhea and compression symptoms; 2. Patients without contraindication of sedation and analgesia; 3. Patients with adenomyosis who have not received other treatment within one year, such as laparoscopy, laparotomy, vaginal surgery, radiofrequency, interventional therapy, etc; There was no GnRH-a treatment within half a year before treatment; 4. Patients with complete preoperative examination; 5. Obtain the consent of patients and their families; 6. Subjects with normal ovarian function.
Exclusion criteria
Exclusion criteria: 1. In patients with a history of lower abdominal surgery and abdominal scar width greater than or equal to 1cm, the acoustic channel was abnormal; The positioning is not successful; 2. Patients with acute inflammation of genital tract; 3. Patients with other gynecological malignant diseases, cervical or endometrial precancerous lesions or canceration, ovarian tumors; 4. Subjects with uterine body larger than 3 months of gestation; 5. Subjects with language communication disorder can not cooperate with sedation and analgesia program; 6. Subjects with pelvic endometriosis requiring surgical treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Median gestational time;Spontaneous abortion rate;live birth rate;Remission of dysmenorrhea;Improvement of menstrual;Reduction of adenomyosis;ovarian function;endometrial receptivity;Depression and anxiety score; | — |
Countries
China
Contacts
Public ContactMin Xue
Xiangya Third Hospital of Central South University
Outcome results
None listed