Effect of lidocaine on postoperative recovery of intestinal function
Conditions
Interventions
lidocaine group:1.5mg/kg (ideal body weight) of lidocaine (total dose not to exceed 100 mg) was given by slow push (approximately 30 seconds) before induction of anesthesia, followed by continuous pum
control group:saline given at the same dose and rate at the corresponding time point
Sponsors
The First Affiliated Hospital of Naval Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients over 18 years old and under 75 years old; 2. Stoma can be used for patients undergoing elective operation; 3. Patients with BMI of 18-30kg / m2.
Exclusion criteria
Exclusion criteria: 1. Patients with gastrointestinal dysfunction before operation; 2. Patients with a history of mental illness or uncontrollable seizures; 3. Patients who are allergic to or contraindicated to the drugs used in this study; 4. Patients with history of alcohol or drug abuse or long-term use of opioids; 5. Patients with severe cardiopulmonary dysfunction, such as severe arrhythmia, heart block, heart failure, hypertrophic cardiomyopathy, dilated cardiomyopathy, pulmonary heart disease and severe valve disease, respiratory failure 6. Patients with severe liver and kidney dysfunction; 7. Patients who are using drugs with incompatibility with lidocaine, such as sodium thiopental, mannitol, sodium nitroprusside, phenobarbital, etc.; 8. Patients who cannot cooperate with the study for any reason; 9. Patients who used other trial drugs or were participating in other clinical trials in the first three months of the study; 10. Patients with severe surgical complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First exhaust time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative opioid dosage;Time for extubation of endotracheal tube;The VAS score of leaving the recovery room;Postoperative Riker score;Opioid dosage within 48 hours after operation;VAS score 24 hours after operation;VAS score 48 hours after operation;First defecation time;First drinking and eating time;Postoperative hospital stay;total duration of hospitalization; | — |
Countries
China
Contacts
Public ContactLulong Bo
The First Affiliated Hospital of Naval Medical University
Outcome results
None listed