fiberoptic bronchoscopy
Conditions
Interventions
Propofol + Alfentanil :Anesthesia induction: give Alfentanil 10µg/kg, and slowly inject propofol 1-1.5mg/kg 1 min later. Anesthesia maintenance: give Alfentanil 0.25-1µg/kg/min, propofol 30-60µg/kg/mi
Propofol+fentanyl : Fentanyl 1µg/kg was given during the induction period, and propofol 1-1.5mg/kg was slowly injected 1 min later. Anesthesia maintenance: propofol 30-60µg/kg/min was given to maintai
Propofol + Remifentanil:Anesthesia induction: Remifentanil 0.5µg/kg, propofol 1-1.5mg/kg. Anesthesia maintenance: Remifentanil 0,025-0.1µg/kg/min, Propofol 30-60µg/kg/min to maintain until the end of
Propofol + Sufentanil :Anesthesia induction: Sufentanil 0.1µg/kg is given, and propofol 1-1.5mg/kg is slowly injected 1 min later. Anesthesia maintenance: propofol 30-60µg/kg/min is given and maintain
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients who intend to undergo bronchoscopy; (2) Age 40-65 years old, no gender limit; (3) ASA I-III level; (4) Body mass index (BMI) 18-30 kg/m 2; (5) Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) For chronic pain, long-term use of analgesics and psychotropic drugs (including opioids, NSAIDs, and Static medicine, antidepressant), alcohol abusers. (2) The liver and kidney functions (ALT, AST, BUN, Cr) are abnormally increased before surgery. (3) A history of recovery from abnormal surgery anesthesia. (4) Have a history of hypertension or enter the operating room to measure systolic blood pressure> 160mmHg or diastolic blood pressure > 95mmHg. (5) Suffering from esophageal reflux disease. (6) Sedatives, antiemetics, and antipruritic drugs were used 24 hours before the operation. (7) It is expected to be difficult to intubate. (8) Perform liver surgery. (9) A history of opioid allergy. (10) Have taken monoamine oxidase inhibitors or antidepressants within 15 days. (11) Subjects in shock. (12) COPD subjects. (13) Pregnant or lying-in woman. (14) Participated in other drug trials within three months or unable to communicate effectively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of cough during induction;The time from the beginning of administration to the onset of cough;Incidence of cough reaction;blood pressure;heart rate;SPO2;BIS value;PETCO2;Ramsay score;Respiratory depression;Drowsiness; | — |
Countries
China
Contacts
Public ContactFang Junbiao
Zhejiang Provincial People's Hospital
Outcome results
None listed