Impact of Goal-Directed Balanced Hydroxyethyl Starch Versus Other Fluid Therapies on Renal Function in Elderly Patients undergoing Total Hip Arthroplasty

Impact of Goal-Directed Balanced Hydroxyethyl Starch Versus Other Fluid Therapies on Renal Function in Elderly Patients undergoing Total Hip Arthroplasty: a Randomized Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100042481

Enrollment

Unknown

Registered

2021-01-22

Start date

2021-02-01

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic diseases

Interventions

HES balanced group: HES 130/0.4 in a balanced electrolyte solution

HES saline group:HES 130/0.4 in a saline solution

Succinylated gelatin group:succinylated gelatin solution

lactated Ringer's group:lactated Ringer's solution

Eligibility

Sex/Gender

All

Age

65 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Subjects aged 65-90 years; 2. Subjects with ASA status I-III undergoing elective total hip arthroplasty under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Subjects with any allergy or contraindication to hydroxyethyl starch (HES) or succinyl gelatin solution; 2. Previous renal failure; 3. Subjects with evidence of coagulation or platelet dysfunction; 4. Patients with infection and malignant tumor; 5. Patients with sepsis; 6. Patients with history of heart failure; 7. Patients with intracranial hemorrhage; 8. Patients taking NSAIDs for a long time.

Design outcomes

Primary

Measure	Time frame
renal function;	—

Secondary

Measure	Time frame
volume effect;hemodynamics change;postoperative complications;anesthesia surgery data;	—

Countries

China

Contacts

Public ContactFuhai Ji

The First Affiliated Hospital of Suzhou University

jifuhai@hotmail.com+86 13656207331

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026