sepsis with hyperglycemia
Conditions
Interventions
Liraglutide group:Use liraglutide to control glucose
Sponsors
Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age over 18 2) Sepsis criteria: According to the diagnostic criteria of Sepsis 3.0 , for infected or suspected infection patients, SOFA = 2 points can be diagnosed as sepsis; qSOFA score is also used, that is, systolic blood pressure = 100 mmHg (1 mmHg=O 133 kPa), respiratory rate (RR) =22 beats/min, changes in consciousness, and two or more positive scores can be diagnosed as sepsis. Diagnosis was reviewed by two attending physicians referring to Sepsis 3.0 to the included patients with sepsis. At the same time, various clinical indicators were used to score SOFA and qSOFA. If there is any objection, please refer to the superior physician for judgment. 3) Patients diagnosed with stress hyperglycemia (blood sugar greater than 10mmol/L) or basic diabetes mellitus at the same time.
Exclusion criteria
Exclusion criteria: 1) Women who are pregnant or breastfeeding or plan to become pregnant during the study period. 2) Patients with type 1 diabetes. 3) Type 2 diabetes, daily insulin dose> 0.5 IU/kg. 4) Are using GLP-1 analogs and DDF-4 inhibitors for treatment, or are severely allergic to any ingredient in liraglutide; 5) History of pancreatic surgery or acute or chronic pancreatitis, personal or family history of medullary thyroid carcinoma, or type 2 multiple endocrine tumor syndrome. 6) Patients with severe kidney damage, eGFR<30ml/min. 7) Subjects who do not follow the research procedures. 8) Questions about the validity of informed consent: Subjects with a history of psychosis, mental retardation, poor motivation, drug abuse (including drugs and alcohol) or other diseases that restrict the validity of informed consent in this study. 9) The researcher thinks it is not suitable to participate in this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| continuous glucose monitoring; | — |
Countries
China
Contacts
Public ContactRongan Liu
Outcome results
None listed