Elderly patients with hypertension
Conditions
Interventions
Group R:0.3mg/kg rimimazolam
Group B:1.5mg/kg propofol
Sponsors
Chancheng District Central Hospital, Foshan, China
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) 65-80 years old, male or female; (2) ASA I -III grade; (3) P0atients who need endotracheal intubation general anesthesia for elective surgery; undergoing elective surgery (tracheal intubation mechanical ventilation; (4) Patients meet the diagnostic criteria of hypertension (systolic blood pressure = 140mmHg and / or diastolic blood pressure = 90mmHg,or patients diagnosed hypertension and are receiving antihypertensive drugs); (5)The subjects understood and signed the informed consen;
Exclusion criteria
Exclusion criteria: (1) patients With craniocerebral injury or intracranial hypertension; (2) patients emergency surgery,hypovolemia,shock or coma; (3) patients Comorbidities include severe cardiopulmonary,liver and kidney dysfunction; previous history of allergic diseases; (4) patients with seated systolic blood pressure = 90mmHg and heart rate less than 50bpm during screening.; (5)Patients with history of drug abuse or alcohol abuse ; (6)Patients with mental system diseases,Long-term history of taking psychotropic drugs and cognitive dysfunction; (7)Pregnancy or lactation patients; (8)Patients who are allergic or contraindicated to research drugs and their components including benzodiazepine, opioid,and flumazenil; (9)Participated in other intervention clinical trials within 3 months before administration; (10)The researcher think not suitable for this study for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of successful anesthesia induction;Incidence of bradycardia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation onset time;Tracheal intubation time;The first intubation success rate;Induction time;Heart rate;Blood pressure;Breath rate;Pulse oxygen saturation;Nacotrend;Modified Observer’s Assessment of Alertne;Other adverse reactions;Percentage of subjects using sedative rescue;Incidence of hypotension;Incidence of hypotension requiring treatment;Incidence of hypertension;Incidence of tachycardia; | — |
Countries
China
Contacts
Public ContactYingchao Xie
Outcome results
None listed