difficult-to-treat rheumatoid arthritis
Conditions
Interventions
Sponsors
Yunnan Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Normal group (1)Age 18 ~ 70 years, gender is not limited; (2)denial of history of rheumatoid arthritis and history of immune diseases; (3)no relevant history of severe acute and chronic diseases; (4)informed consent, voluntary test. 2. The initial untreated group (1)In line with the diagnostic criteria of RA Western medicine, and damp-heat obstruction syndrome of TCM diagnostic criteria; (2)aged 18-70 years, gender; (3)initial diagnosis without anti-RA drug treatment; (4)the disease was active, DAS28 > 2.6. 3. Effective treatment group (1)In line with RA western medicine diagnostic criteria, 1995 ACR20 treatment effective standard, and damp-heat obstruction syndrome of TCM diagnostic criteria; (2)aged 18 – 70 years, gender unlimited; (3)patients who were treated with DMARDs for more than half a year without using biological agents and hormones, were in remission, did not affect normal learning and work, and could take care of themselves; (4)DAS28 3.2; (5)patients whose symptoms did not meet the ACR20 remission standard; (6)sign informed consent, voluntary test.
Exclusion criteria
Exclusion criteria: (1) Patients who do not use the medicine according to the regulations cannot cooperate; (2) Pregnant or lactating women; (3) People who are currently infected with bacteria or viruses, or who are mentally or legally disabled; People with allergies or allergies to drugs such as methotrexate; (4) Patients participating in other clinical trials; (5) Patients with severe heart, liver and kidney dysfunction and accompanied by other malignant tumors; (6) Those who have used biological agents and hormones within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRNA and protein expression levels of p-glycoprotein;Protein mRNA anssion levels in breast cancer;DAS28;Rheumatoid factor;Anti-cyclic citrullinate peptide antibody;C-reactive protein;Blood sedimentation;Number of joint tenderness;Joint swelling number;Therapeutic Effect of TCM Diseases;TCM syndrome scores;Patients were assessed by VAS scale of pain;Patients were assessed for overall disease status VAS score;The overall disease status VAS score was assessed by the investigator; | — |
Countries
China
Contacts
Public ContactLi Zhaofu
Medical Ethics Committee of Yunnan Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine
Outcome results
None listed