Brain protection
Conditions
Interventions
Lung dynamic compliance group:Positive end expiratory pressure was titrated according to pulmonary dynamic compliance
control group:PEEP=0 group
Sponsors
Shanghai First People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: The patients who were scheduled for thoracoscopic lobectomy had no severe liver and kidney dysfunction, no bleeding and coagulation dysfunction, no nervous system and mental system diseases before operation, no use of drugs that may affect hemodynamics and other unauthorized drugs before operation, and signed the informed consent.
Exclusion criteria
Exclusion criteria: Patients with severe circulatory system diseases, or severe liver and kidney dysfunction; preoperative use of drugs that may affect hemodynamics and other unauthorized; absolute and relative contraindications of esophageal ultrasound (esophageal stenosis, diverticulum, perforation, tumor; recent upper gastrointestinal bleeding, surgery; esophageal varices, esophageal hiatal hernia, etc.); language communication disorders; hearing, vision Patients with memory impairment; patients with mental illness and taking antipsychotic drugs before operation; patients with sedatives, anti anxiety drugs and sleeping pills before operation; patients with neurological diseases before operation, such as cerebral embolism, cerebral hemorrhage, dementia, etc.; history of alcohol abuse; patients without signing informed consent; patients with thoracoscopic surgery converted to open surgery; patients with accidents (including hemodynamic disorders) during operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral oxygen saturation;Cardiac output;VTI;Aortic diameter; | — |
Countries
China
Contacts
Public ContactLianhua Chen
Outcome results
None listed