Pain after knee arthroplasty
Conditions
Sponsors
Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) 50 to 75 years of age. (2) Osteoarthritis of knee joint was diagnosed and unilateral total knee arthroplasty was performed under general anesthesia in hospital. no surgical contraindications, and agreed to participate in this trial. (3) the American Association of Anesthesiologists (ASA) is classified as I or II. (4) all the affected limbs were right knee. (5) all of them are right-handed. (6) consent and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) There was deep venous thrombosis or swelling of lower extremities before operation. (2) Severe arrhythmias, heart failure, chronic obstructive pulmonary disease, epilepsy, mental illness. (3) Patients with brain injury were found after baseline fMRI examination. (4) There were obvious mood swings within 24 hours before fMRI scan. (5) Drinking alcohol, coffee, strong tea, etc., within 24 hours before fMRI scan. (6) During fMRI scan, severe structural or deterministic injuries were found on both sides of the skull. (7) If acute or serious events or adverse events occur during the study, they should not continue to participate in the trial. (8) Patients who received other related treatments on their own during the trial. (9) Poor compliance, repeated explanations are still unwilling to participate in the test, or unable to complete the test cycle.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting state BOLD-fMRI detection index: low frequency amplitude (ALFF), fractional low frequency amplitude (f ALFF), local consistency analysis (ReHo), functional connection (FC).;Pressure pain threshold; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue score (VAS) (includes pain during rest and activity);4m walking test; | — |
Countries
China
Contacts
Public ContactXiao Lianbo
Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed