Polycystic ovary syndrome
Conditions
Interventions
GLP-1RA group:GlP-1RA in combination with metformin for 3 months
Diane-35 group:Diane-35 in combination with metformin for 3 month, 1 month washout period, GlP-1RA in combination with metformin for 3 months.
Sponsors
Department of Endocrinology, Xinqiao Hospital, the Third Military Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: The diagnostic criteria of PCOS included in the study were PCOS recommended by ESHRE / ASRM of Rotterdam in 2003. That is, the clinical manifestations of rare ovulation or anovulation, hyperandrogenemia or hyperandrogenism, and polycystic ovarian changes under ultrasound can be diagnosed if two of the above three items are met. 1. BMI >= 24kg / m2 or waist circumference >= 85CM. 2. Aged 18 to 50 years.
Exclusion criteria
Exclusion criteria: 1. Patients with PCOS and other infertility diseases; 2. Patients with obvious symptoms and signs of liver and kidney diseases, or ALT 2 times higher than the upper limit of normal, serum creatinine more than 110 mmol / L (1.3 mg / GL); 3. Patients with PLT < 60 * 10 ^ 9 / L and Hb < 100g / L; 4. Patients who can't take effective contraceptive measures during the trial; 5. Patients who had used metformin or other insulin sensitizers within one month before selection; 6. Patients with malignant tumor; 7. Patients with history of vascular disease, thyroid disease, smoking, diabetes and hypertension should be carefully studied; 8. Patients with infection, trauma, surgery and other emergency situations; 9. Patients with cardiovascular disease, thyroid disease, smoking, diabetes and hypertension; 10. There are other cases that can not participate in the completion of intervention follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routine examination;thyroid function;Liver and kidney function;sex hormone; fasting blood glucose;glycosylated hemoglobin;fasting insulin;insulin release test;blood lipid;Color doppler ultrasound in gynecology;Glucose clamp test;Inflammatory biomarkers;body mass index;WHR;AMH; | — |
Countries
China
Contacts
Public ContactLiao Mingyu
Department of Endocrinology, Second Affiliated Hospital of Army Medical University (Xinqiao Hospital)
Outcome results
None listed