Postoperative cognitive dysfunction
Conditions
Interventions
PETCO245-55mmHg:none
PETCO255-65mmHg:none
PETCO265-75mmHg:none
Sponsors
Yunnan First People's Hospital Affiliated to Kunming University of Science and Technology
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects who underwent single wedge lung resection; 2. Subjects with operation time < 2 hours and intraoperative blood loss < 300 ml; 3. Subjects without extensive thoracic adhesions; 4. ASA I - II subjects; 5. Subjects without other contraindications of paravertebral nerve block and intercostal nerve block.
Exclusion criteria
Exclusion criteria: 1. The subjects who refused the operation or anesthesia plan had a history of thoracoscopic surgery; 2. Patients with moderate to severe chronic obstructive pulmonary disease (COPD) had preoperative hypoxemia (PaO2 50 mmHg) and severe acute pulmonary infection; 3. Patients with arrhythmia indicated by preoperative examination have cardiac insufficiency; 4. Coagulation dysfunction in patients with local anesthetic allergy; 5. Subjects with body mass index (BMI) > 28 kg / m2; 6. Patients with extensive pleural adhesion or complicated lobectomy or segmental resection; 7. Patients transferred to double lumen endotracheal tube or thoracotomy; 8. Patients with neuropsychiatric diseases or other important organ dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentration of Aß-42 and S100ß in the serum;cerebral oxygen saturation;concentration of inflammatory factor in the serum;mini- mental state examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time of tracheal catheter removal;PACU retention;the incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactHua Jin
Yunnan First People's Hospital Affiliated to Kunming University of Science and Technology
Outcome results
None listed