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Comparative study of the W&W strategy and local exsection in patients with CCR after total neoadjuvant therapy (TNT) in locally advanced low rectal cancer

Comparative study of the W&W strategy and local exsection in patients with CCR after total neoadjuvant therapy (TNT) in locally advanced low rectal cancer

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100042358
Enrollment
Unknown
Registered
2021-01-21
Start date
2021-02-20
Completion date
Unknown
Last updated
2021-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rectal cancer

Interventions

group W&W:chemotherapy
group local exsection:The local excision was followed by chemotherapy

Sponsors

The Second People's Hospital of Yibin City
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: A) The preoperative pathological diagnosis was confirmed as rectal adenocarcinoma, with the lower margin of the tumor <= 7cm from the anal margin; B) Preoperative magnetic resonance staging CT3-4N1-2M0; C) The patient is 18-80 years old; D) The patient and/or the authorized family members understand and agree to complete neoadjuvant chemoradiotherapy, and sign the consent form; E) After neoadjuvant chemoradiotherapy, the patient was assessed as a clinical complete response by abdominal MRI, colonoscopy, digital rectal examination and intra-rectal ultrasound; F) The patient and/or the authorized family members should understand and choose the observation and waiting strategy or perform local surgical resection, and sign the consent form.

Exclusion criteria

Exclusion criteria: A) Patients with perforation, obstruction, massive hemorrhage and other emergency diseases in the process of diagnosis and treatment; B) Distant metastasis is found during diagnosis and treatment; C) People with a history of mental illness; D) Those who cannot tolerate whole-course neoadjuvant radiotherapy or neoadjuvant radiotherapy or chemotherapy without standard.

Design outcomes

Primary

MeasureTime frame
complication;Local recurrence rate;survival time;

Countries

China

Contacts

Public ContactWu Miao

The Second People's Hospital of Yibin City

1334665301@qq.com+86 13990905852

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026