Cervical distonia (CD)
Conditions
Interventions
experimental group:Based on SPECT examination, botulinum toxin is concentrated in the radiation-rich area of the muscles responsible for spasm
control group:Based on SPECT examination, botulinum toxin is evenly distributed in the muscles responsible for spasm.
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-75 years, no gender limit; (2) Subjects have a clear understanding of the purpose of the study, are willing and able to complete the study, and sign informed consent; (3) Meet the diagnostic criteria for primary CD; (4) The symptoms of CD lasted for at least 1 month; (5) No history of surgical treatment for CD, and oral antispasmodic drugs were not effective; (6) No history of BTX-A injection or at least 3 months from the last injection.
Exclusion criteria
Exclusion criteria: (1) Congenital muscular torticollis or abnormal head and neck posture due to tumor, trauma, drugs, and other factors; (2) Patients with primary CD only manifested as tremor; (3) Unwillingness to receive BTX-A injection or allergy to BTX-A and its related components; (4) Patients who are currently taking medications interfering with neuromuscular conduction; (5) Pregnant and lactating women; (6) Infections or skin lesions at the injection sites; (7) Patients with unstable severe cardiovascular, renal, and respiratory system diseases; (8) Patients with severe cognitive impairment or mental illness that affected the clinical evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TWSTRS score reduction rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tsui score reduction rate;Number of injection sites;Time spent in treatment;VAS pain score; | — |
Countries
China
Contacts
Public ContactJin Lingjing
Shanghai Tongji Hospital
Outcome results
None listed