Abdominal Aortic Aneurysms
Conditions
Interventions
GAR1 group:Remazolam group was induced at 6mg/kg/h and maintained at 1~2mg/kg/h.
GAR2 group:Remazolam group was induced at 12mg/kg/h and maintained at 1~2mg/kg/h
GAP group:Propofol group was induced at 2~2.5mg/kg, at 4~12mg/kg/h Maintenance
LA group:outine local infiltration anesthesia
Sponsors
Zhuhai People's Hospital Affiliated with Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. AAA was diagnosed by CT, MRI or (and) ultrasound at the time of admission, evaluated by a specialist and met the criteria for elective EVAR surgery [3], and the hospital stay was >= 3 days (including the time before and after surgery); 2. 18 years old <= age <= 80 years old, American anesthesiologist classification ASA <= III; 3. Clearly understand the experimental process and voluntarily participate in the study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. People who are known to be allergic to benzodiazepines or have severe allergies and family history; 2. Long-term use of opioids, psychiatric sedatives or non-steroidal anti-inflammatory drugs; 3. Symptomatic ischemic heart disease (such as unstable angina), moderate or severe decompensated heart failure, severe heart valve disease, obvious abnormal heart rhythm; 4. History of symptomatic cerebrovascular disease; 5. Severe or extremely severe respiratory function decline (such as FEV1/FVC 170µmol/L) 7. Severe liver function decompensation (such as AST/ALT >= 2.5ULN, ALB < 2.0g/dL); 8. Past mental illness history; 9. The researcher thinks it is not suitable to participate in this clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MAP;BIS;CI;SVI;MOAA/S;NIH Stroke Scale;levels of GABA;levels of Ang II;levels of Ang1-7;levels of IL-6;levels of IL-10;MACI;30-day mortality; | — |
Countries
China
Contacts
Public ContactLiang Gen-Qiang
Zhuhai People's Hospital Affiliated with Jinan University
Outcome results
None listed