adolescent and early adult depression
Conditions
Interventions
Group 1:single intermittent theta burst stimulation per day +antidepressant
Group 2:repeated intermittent theta burst stimulation per day+antidepressant
Group :sham stimulus + antidepressant
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of DSM-5 depressive disorder and bipolar disorder;Patients with bipolar disorder are currently in a state of depression, and there is no mania or hypomania for nearly half a year; 2. Did not use any psychiatric drugs within 4 weeks before enrollment (use of psychiatric drugs prior to 4 weeks is allowed); 3. Aged 12-25; HAMD-17 score > 7 points; 4. Obtain written informed consent of the patient.Minors or incapacitated during the period of illness shall obtain the written informed consent of their legal guardian.
Exclusion criteria
Exclusion criteria: 1. Meet the dsm-iv axis I any other diagnostic standard; 2. Pregnant and claustrophobic 3. History of organic brain disease, brain injury or surgery; 4. Intolerance to major physical diseases such as heart, liver and kidney; 5. Received MECT treatment within 3 months; 6. Previous history of epileptic seizure; 7. Contraindications for MRI examination; 8. There are contraindications for TMS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale 17 item version (HDRS-17); | — |
Countries
China
Contacts
Public ContactYuping Ning
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed