acute myocardial infarction
Conditions
Interventions
1:Sacubitril/Valsartan
2:Valsartan
Sponsors
The Seventh People's Hospital of Zhengzhou
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Patients diagnosed as spontaneous AMI according to the guidelines, onset within 7 days; 3. Hemodynamic stability: SBP >= 100 mmHg in patients treated with ACEI/ARB within 24 hours before randomized; Randomized patients who were not treated with ACEI/ARB drugs in the first 24 hours had SBP >= 110 mmHg; Diuretics, vasodilators, vasopressors, and/or positive inotropic agents were not used within 24 hours prior to randomization.
Exclusion criteria
Exclusion criteria: 1. Patients with a prior history of chronic heart failure were randomized; 2. Patients were randomized to the first 24 hours of cardiogenic shock; 3. Randomized patients with persistent heart failure; 4. Myocardial infarction patients planning CABG; 5. The clinical presentation is obvious in patients with right ventricular MI; 6. Symptomatic hypotension was present at screening; 7. A history of angioedema in a patient; 8. Patients with known or suspected bilateral renal artery stenosis; 9. Patients with apparent obstructive cardiomyopathy; 10. Patients who have recently undergone or are planning to undergo cardiac surgery; 11. eGFR = 5.2mmol/L at random(or hyperkalemia); 13. A history of liver damage or fibrosis is known; 14. LCZ696 history of use; 15. Cancer patients; 16. Allergy, intolerance or contraindications to ACEI/ARB/NEPI; 17. Pregnancy or lactation.
Countries
China
Contacts
Public ContactYujie Zhao
The Seventh People's Hospital of Zhengzhou
Outcome results
None listed