Sepsis
Conditions
Interventions
sodium bicarbonate ringer's solution:This group was treated with Sodium Bicarbonate Ringer's Solution
normal saline:This group was treated with normal saline.
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosed as sepsis or septic shock according to the definition of Sepsis-3.0 with fluid resuscitation requirement; 2.Aged between 18 and 80, male or female; 3.Signed informed Consent (with delay within 24 hours).
Exclusion criteria
Exclusion criteria: 1.Patients with hypermagnesemia; 2.Patients with hypothyroidism; 3.Patients predicted to die or discharged within 24 hours after admission; 4.Patients with previous history of mental illness, severe hepatic and renal insufficiency, severe cardiac disease, primary severe central nervous system lesions; 5.Pregnant or breast-feeding women; 6.Patients who have received cardiopulmonary resuscitation 7.Patients who participated in other clinical trials within 30 days; 8.Patients have other conditions that are not appropriate for inclusion according to the researcher's judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in SOFA value at 24h; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum lactate clearance rate at 6h;The proportion of patients with serum lactate clearance rate>30% at 6h and 24h;Changes in pH value over time, and the lowest pH value during hospitalization;Changes in base residue (BE value) over time;Changes in serum bicarbonate(HCO3-) over time;The proportion of patients with hyperchloremia;Changes in SOFA score over time;Changes in APACHEII score over time;Mechanical ventilation time(h);The proportion of patients receiving RRT; | — |
Countries
China
Contacts
Public ContactLina Zhang
Xiangya Hospital of Central South University
Outcome results
None listed