Off-pump Coronary Artery Bypass Grafting
Conditions
Interventions
experimental group A:The anesthesia was induced with 0.2mg/kg remimazolam besylate
experimental group B:The anesthesia was induced with 0.3mg/kg remimazolam besylate
experimental group C:The anesthesia was induced with 0.4mg/kg remimazolam besylate
control group:The anesthesia was induced with 0.1mg/kg midazolam
Sponsors
Beijing Anzhen Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 35-70, regardless of gender; 2. Patients of American Society of anesthesiologists (ASA) grade II-III; 3. Subjects undergoing off-pump coronary artery bypass grafting; 4. Patients who voluntarily participated in the study and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are known to be allergic to rimazole besylate or have a history of severe allergy or family history in the past; 2. Patients with long-term use of narcotic analgesics, sedatives or non steroidal anti-inflammatory drugs; 3. Opioid dependent or opioid tolerant subjects; 4. Patients with severe lung, liver and kidney dysfunction; 5. Patients with serious arrhythmia; 6. Patients with acute myocardial infarction; 7. Subjects of emergency operation; 8. Subjects considered unsuitable for the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BIS;Modified Observer's Assessment of Alertness/Sedation;Heart rate;Mean arterial pressure;Central venous pressure;Cardiac index;Stroke volume index;Awakening time;Extubation time;ICU stay; | — |
Countries
China
Contacts
Public ContactLin Duomao
Beijing Anzhen Hospital
Outcome results
None listed