Effect of sevoflurane anesthesia on delayed recovery of neurocognitive function in elderly patients after joint replacement: a randomized controlled study

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100042305

Enrollment

Unknown

Registered

2021-01-17

Start date

2021-01-11

Completion date

Unknown

Last updated

2021-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delayed neurocognitive recovery

Interventions

experimental group:Inhaled sevoflurane

control group:Nil

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Subjects older than or equal to 65 years old; 2. Subjects with ASA grade I - III; 3. Subjects without abnormal heart, liver and kidney function; 4. Subjects undergoing joint replacement under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Patients with preoperative history of schizophrenia, epilepsy, Parkinson's disease, cognitive impairment or myasthenia gravis; 2. Patients with poor preoperative communication due to coma, severe dementia, language disorder or serious disease; 3. Subjects with a history of alcohol abuse or drug abuse; 4. Subjects with poor compliance can not cooperate with the examination; 5. Subjects taking antidepressants for a long time, anticholinergic drugs, anticonvulsants or sedatives.

Design outcomes

Primary

Measure	Time frame
Delayed neurocognitive recovery;	—

Countries

China

Contacts

Public ContactZhang Mengyuan

Shandong Provincial Hospital

zhangmy717@163.com+86 15168886767

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026