Transient ischemic attack or minor stroke
Conditions
Interventions
Experimental group:Butylphthalide combined with Ticagrelor
Control group:placebo combined with Ticagrelor
Sponsors
Heze Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. With transient ischemic attack (TIA): a transient episode of neurological dysfunction caused by focal brain, spinal cord, or retinal ischemia, without acute infarction. 2. Patients with three or more attacks in the last 24 hours.
Exclusion criteria
Exclusion criteria: 1. Head CT or MRI plain scan found intracranial hemorrhage,aneurysm or other neurological symptoms which cannot accept the treatment; 2. Thrombolysis,anticoagulation therapy,carotid or cerebral or coronary artery stent implantation or reconstruction in Plan; 3. Being allergic to NBP, clopidogrel and aspirin; 4. With a history of ventricular aneurysm,atrial fibrillation or suspected cardiovascular embolism causing TIA; 5. Patients having taken NSAIDS for more than 7 days recently; 6. With a history of gastrointestinal bleeding within 6 months; 7. With a history of a major surgery within 30 days; 8. With coagulation dysfunction; 9. With previous history of non-traumatic intracranial hemorrhage; 10. With severe liver and kidney dysfunction; 11. Pregnancy or lactation; 12. Patients who do not understand or cooperate with the study, treatment or follow-up. Additionally, standard treatments such as hypoglycemic and antihypertensive therapy may be prescribed to all patients at the discretion of the investigators and clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a compound event of Stroke, TIA, ACS or death on days 7 and 90; | — |
Countries
China
Contacts
Public ContactChen Yankun
Heze Municipal Hospital
Outcome results
None listed