Cholangiocarcinoma
Conditions
Interventions
doxorubicin loaded microparticles :Intraperitoneal perfusion combined with biliary support tube perfusion
Sponsors
Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients must meet all of the following inclusion critetia to be allowed to participate in this study: (1) Cholangiocarcinoma was diagnosed by preoperative pathological examinarion or clincal examinarion; (2) Patients who had not received intravenous chemotherapy,radiotherapy or local administration of cholangiocarcinoma in the past four weeks: (3) ECOG score between 0-2 points; (4) The expected survival time was more than three months; (5) THe age was between 18-70 years old; (6) THe coagulation function was normal(prothrombin internaional normalized ratio INR = 60 mL/min; (8) No other serous cardiopulmonary diseases; (9) The patients agreed to be enrolled and signed the informed consent.
Exclusion criteria
Exclusion criteria: Patients with one of the following conditions cannot enter or continue the study: (1) A woman who is breatfeeding,pregnant or preparing for pregnacy; (2) Patients who are known to be allergic to test sample components or their analogues; (3) Patients with congnitive impairment or poor treatment compliance determined by researchers; (4) Parcicipants in other clinical trials within four weeks; (5) Patients with contraindications of intraperitoneal perfusion/biliary support tube perfusion; (6) Other severe,acute or chronic diseases that mat inerfere with the results of this study; (7) Patients who was not suitable for clinical trials judged by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival, OS;progression-free survival, PFS;Local recurrence, abdominal implant metastasis or distant metastasis; | — |
Countries
China
Contacts
Public ContactWan Chidan
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed