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Effect of intranasal oxytocin on early remission of cerebral vasospasm in patients with subarachnoid hemorrhage after ruptured intracranial aneurysm

Effect of intranasal oxytocin on early remission of cerebral vasospasm in patients with subarachnoid hemorrhage after ruptured intracranial aneurysm

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100042282
Enrollment
Unknown
Registered
2021-01-17
Start date
2021-01-18
Completion date
Unknown
Last updated
2021-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral vasospasm

Interventions

experimental group:Oxytocin 4IU nasal drops

Sponsors

Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Patients with ruptured intracranial aneurysms were admitted to hospital within 24 hours after the onset of subarachnoid hemorrhage; (2) Cerebral vasospasm was diagnosed during hospitalization, and cerebrospinal fluid and blood tests were performed; (3) Subarachnoid hemorrhage was caused by ruptured intracranial aneurysms and received endovascular interventional therapy. (4) Patients with spontaneous and non-invasive subarachnoid hemorrhage received vasospasm monitoring during lumbar puncture.

Exclusion criteria

Exclusion criteria: (1) Underlying diseases of cardiovascular, renal, respiratory, endocrine, psychiatric and neurological disorders; (2) Diagnosed with other SAH with a history of craniotomy or endoscopic surgery; (3) Receiving drugs that affect metabolism or appetite, such as clocaine, topiramate and metformin; (4) Use of antiplatelet and anticoagulant drugs or immunosuppressants within 6 months before recruitment. (or 5) cerebral vasospasm caused by improper intravascular operation.

Design outcomes

Primary

MeasureTime frame
Cerebral vascular blood flow;

Countries

China

Contacts

Public ContactWenfeng Feng

Southern Medical University

905528697@qq.com+86 16620168005

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026