Narcolepsy
Conditions
Interventions
experimental group:10,000lx Bright Light Therapy
control group:<200lx Dim light
Sponsors
Peking University Sixth Hospital/Institute of Mental Health
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria of narcolepsy in the International Classification of Sleep Disorders (ICSD-3); 2.The score of Hamilton Depression Rating Scale (HAMD-17) is more than 7; 3.The score of Epworth Sleepiness Scale (ESS) is not less than 12; 4.Use of stable narcolepsy treatment (modafinil hydrochloride methylphenidate tricyclic antidepressants, etc.) regimen at least 4 weeks before study screening; 5.Stable use of antidepressants (no or stable use of antidepressants at least the past 4 weeks).
Exclusion criteria
Exclusion criteria: 1.Meet the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV)-TR criteria for Axis I comorbidities (e.g., schizophrenia, substance abuse/dependence, bipolar disorder, etc.) 2.Serious suicidal intention or suicidal behavior; 3.Other diseases that can cause drowsiness, such as other sleep disorders, psychiatric diseases, neurological diseases or the influence of drugs; 4.Has crossed 2 or more time zones in the last 3 months; 5.Visual abnormalities that interfere with phototherapy, such as obvious cataract narrow Angle glaucoma, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| score of HAMD;Cortisol awakening response, CAR; | — |
Secondary
| Measure | Time frame |
|---|---|
| score of ESS; | — |
Countries
China
Contacts
Public ContactSifan Hu
Peking University Sixth Hospital /Institute of Mental Health
Outcome results
None listed