The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100042252

Enrollment

Unknown

Registered

2021-01-17

Start date

2021-02-01

Completion date

Unknown

Last updated

2021-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pharmacodynamics

Interventions

Group P:Normal saline

Group SK0.25:esketamine 0.25mg/kg

Group SK0.5:esketamine 0.5mg/kg

Eligibility

Sex/Gender

All

Age

65 Years to 89 Years

Inclusion criteria

Inclusion criteria: (1) The age of patients is between 65-89 years; (2) ASA classification is I-III; (3) body mass index (BMI) 19-27 k.m-2.

Exclusion criteria

Exclusion criteria: (1) Patients who are allergic to either propofol or esketamine; (2) Long-term use of analgesics; (3) Alcoholism; (4) Nervous system or schizophrenia; (5) Late liver or Kidney disease; (6) Sleep apnea syndrome; (7) Uncontrolled hypertension, blood pressure higher than 180/120mmHg; (8) Users of psychotropic drugs.

Design outcomes

Primary

Measure	Time frame
Blood pressure, Heart rate;	—

Countries

China

Contacts

Public ContactHua Yang

Department of Anesthesiology, Shanghai Yangpu District Shidong Hospital

yanghuayanghua1977@163.com+86 21-25066782

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026