Valvular disease
Conditions
Interventions
intervention group:left atrial appendage excision
Sponsors
Fuwai Hospital, Chinese Academy of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Over 18 years of age; 2. At least undergoing mitral valve or aortic valve surgeries; 3. Without baseline atrial fibrillation and atrial flutter; 4. With CHA2DS2-VASc score >= 2; 5. Agreed to participate in the clinical study and consented to annual postoperative ultrasound examinations and telephone follow-ups.
Exclusion criteria
Exclusion criteria: 1. Undergoing heart transplantation, or complex congenital heart surgery, or ventricular assist device implantation; 2. Redo cardiovascular surgeries; 3. Left atrium diameter over 6 cm; 4. Presence of thrombus in the left atrium or LAA; 5. With a history of stroke/cerebrovascular accident within one month before surgeries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A composition of newly occurred ischemic stroke /transient ischemic attack, and cardiovascular mortality during the 1-year, 3-year, 5-year follow up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative AF (defined as newly diagnosed AF within 30 postoperative days), cardiovascular mortality, newly occurred ischemic stroke, newly occurred transient ischemic attack, newly occurred hemorrhagic stroke, bleeding events during the 1-year, 3-year, 5-year follow up.; | — |
Countries
China
Contacts
Public ContactHansong Sun
Fuwai Hospital, Chinese Academy of Medical Science
Outcome results
None listed