Postpartum Depression
Conditions
Interventions
Experimental Group:Esketamine
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-II subjects; 2. Women of childbearing age; 3. Those parturients who give full-term delivery for cesarean section and spinal anesthesia; 4. Volunteers who have signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects with pregnancy induced hypertension, thyroid dysfunction, preeclampsia and eclampsia, psychosis, and inability to communicate pain response; 2. Subjects with abnormal increase of uterine activity, such as ankylosing uterine contraction, placental abruption and umbilical cord prolapse; 3. Subjects with contraindications of epidural catheterization such as spinal trauma or deformity; 4. Opioid allergy or history of drug abuse; 5. Patients with serious risk of elevated blood pressure or intracranial pressure; 6. Patients with poorly controlled or untreated hypertension; 7. Subjects with severe fetal abnormalities; 8. Subjects with pernicious placenta previa; 9. Patients who have been given labor analgesia; 10. Subjects of emergency operation; 11. Other conditions considered by the researcher not suitable for the treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postpartum depression at 1 month;Pain score of Parturient and times of analgesia pump pressing within 48 hours after delivery;EPDS scores of 1D, 3D, 7d, 1 month, 3 months and 6 months postpartum;Sleep quality of Parturient at 1D, 3D, 7d, 1 month, 3 months and 6 months after delivery;The score of anxiety of parturient at 1D, 3D, 7d, 1 month, 3 months and 6 months after delivery;The quality scores of Parturient were recovered at 1D, 3D, 7d, 1 month, 3 months and 6 months; | — |
Countries
China
Contacts
Public ContactE Wang
Xiangya Hospital of Central South University
Outcome results
None listed