Postoperative cognition
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who plan to receive elective surgery for gastrointestinal tumors; 2. Subjects over 65 years old, regardless of gender; 3. Subjects with ASA grade I - III; 4. Subjects with operation time more than 2 hours; 5. Those subjects who have a detailed understanding of the nature, significance and possible benefits of the trial before the trial, the possible inconvenience and potential risks, understand the research procedures and sign the informed consent voluntarily in writing.
Exclusion criteria
Exclusion criteria: 1. Subjects who are allergic to the active ingredients of esmketamine or the narcotic drugs used; 2. Patients with serious risk of elevated blood pressure or intracranial pressure; 3. Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic / diastolic blood pressure over 180 / 100mmhg); 4. Patients with hyperthyroidism without treatment or insufficient treatment; 5. Subjects with central nervous system diseases (such as Alzheimer's disease); 6. Subjects taking sedatives or antidepressants; 7. Subjects with alcohol or drug dependence; 8. Subjects unable to complete the neurocognitive function test; 9. Subjects with severe visual, auditory or communication impairment; 10. Subjects with a history of cerebrovascular accident within three years; 11. Subjects with MMSE < 23 before operation; 12. Subjects who are unable to communicate effectively with the researchers or who are considered unsuitable by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperation cognitive score; | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP;S-100ß protein; | — |
Countries
China
Contacts
Public ContactWang Xiuhong
The First Affiliated Hospital of Nanchang University
Outcome results
None listed