Cesarean section
Conditions
Interventions
Low dose of esketamine group :Intravenous administration of 0.50 mg / kg of esketamine
Normal dose of esketamine group:Intravenous administration of 0.75 mg / kg of esketamine
Control group :Intravenous administration of the same volume of normal saline
Sponsors
Department of Anesthesia and Surgery of Hunan Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. ASA I-II,aged 23-39 years; 2. Single pregnancy,37-42 weeks of gestation, normal placental function; 3. Contraindication of intraspinal anesthesia and the need for general anesthesia cesarean section patients, including thrombocytopenia (less than 70 x 10^9 / L), lumbar disc prolapse, lumbar trauma, etc.
Exclusion criteria
Exclusion criteria: 1. Maternal complicated with eclampsia, preeclampsia and cardiovascular disease; 2. Previous neurological or mental illness, difficult cooperation between doctors and patients; 3. The body weight is more than 100kg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apgar scores;Neonatal neurobehavioral score;Changes of vital signs of puerpera;I-D interval consciousness; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;Effective pressing times of analgesia pump;Time needed for additional analgesia for the first time;Wound pain;Ramsay score;Postoperative adverse reactions;Maternal depression;Liver and kidney function of patients;Length of stay and hospitalization expenses; | — |
Countries
China
Contacts
Public ContactZhang Jie
Hunan Maternal and Child Health Care Hospital
Outcome results
None listed