Chronic pain after surgery
Conditions
Interventions
Observation Group SK:Before induction of general anaesthesia, a low dose of S(+)-ketamine 0.5mg/kg was diluted with normal saline to 10ml for intravenous injection
Control Group C:Before induction of general anesthesia, 10ml normal saline should be injected intravenously
Sponsors
Drum Tower Hospital, Nanjing, Jiangsu
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients selectively undergoing elective two-port video-assisted thoracoscopic surgery for unilateral pulmonary lesion 2. Male or female; aged 18-65; ASA I-III level; BMI 18 to 30 Kg/m2; 3. Join voluntarily and sign informed consent; 4. Patients who transferred to the general ward after operation.
Exclusion criteria
Exclusion criteria: 1. Patients with severe hypertension, intracranial space occupation or intracranial hypertension;recent brain injury, cerebral infarction, cerebral hemorrhage patients;patients with other systemic tumors or severe organ; dysfunction; Patients with glaucoma and hyperthyroidism; 2. Patients with mental or neurological diseases, cognitive and language dysfunction, and low level of education, unable to cooperate with the follow-up; 3. Patients with the history of chronic pain; 4. Patients with the substance abuse or dependence like analgesics, antianxiety drugs, sleeping pills; 5. Patients having a history of recovery from abnormal surgical anesthesia; 6. Patients who are allergic to the test drugs; 7. Patients undergoing thoracoscopic mediastinal, pleural and other non-pulmonary masses resection; 8. patients with clearly diagnosed recurrence or metastasis of malignant tumors after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and severity of chronic pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital signs;Types and dosages of postoperative analgesic drugs;Incidence of postoperative acute pain and pain score;times of pressing analgesic pump,Dose and type of analgesic drugs;Drug-related adverse reactions;Postoperative complications during hospitalization and Clavien-Dindo classification;the scores of anxiety and sleep on 1d and 3d after operation;The incidence of pain, the score of pain, types and dosages of analgesics used on 30 days after operation; | — |
Countries
China
Contacts
Public ContactRong Zhou
Drum Tower Hospital, Nanjing, Jiangsu
Outcome results
None listed