Vascular Dementia
Conditions
Sponsors
Hubei University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The age of the subjects was 35-85 years old; 2. It was in accordance with the diagnostic standard of Western medicine for vascular dementia; 3. It is in accordance with the diagnostic standard of TCM phlegm and blood stasis syndrome of vascular dementia; 4. They signed informed consent and volunteered to participate in the study; 5. The patients are expected to follow up within half a year.
Exclusion criteria
Exclusion criteria: 1. Early memory impairment with progressive deterioration, early prominent features of Parkinson's disease, and primary nervous system diseases (such as multiple sclerosis, encephalitis, etc.); 2. There was no vascular lesion in neuroimaging examination; 3. Other diseases that can explain cognitive impairment, such as brain tumor, multiple sclerosis,encephalitis, depression, poisoning, and systemic diseases and metabolic abnormalities that significantly affect cognitive function; 4. Severe heart, brain, liver and hematopoiesis diseases, or other serious diseases affecting their survival; 5. Drug or alcohol abuse / dependence within 3 months before participating in the trial; 6. Pregnant and lactating women; 7. Patients with severe mental disorders (perception disorders, thinking disorders); 8. For known renal insufficiency, serum creatinine (CR) was higher than 221 umol/L in male and 177 umol/L in female; 9. Patients with known liver dysfunction, alanine aminotransferase (ALT) > times of normal value or with cirrhosis; 10. The researchers believe that there are other situations that are not suitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Mini Mental State Examination, MMSE;Activity of Daily Living, ADL;Integral Scale for Phlegm Turbidity and Blood Stasis Syndrome in Vascular Dementia; | — |
Secondary
| Measure | Time frame |
|---|---|
| transcranial Doppler, TCD;Blood lipids;Inflammatory factors;Oxidative stress; | — |
Countries
China
Contacts
Public ContactHeyuan Shi
Hubei University of Chinese Medicine
Outcome results
None listed