destroyed lung
Conditions
Interventions
Surgical Arm:Removing Destroyed Lung
Medicinal Arm:Standard Treatment with internal medicines
Sponsors
The Third Hospital of Zhangzhou
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Participants with subjective breathing difficulty or dyspnea; 2. The extent of the destroyed lung; We recruited the participants with destroyed lung restricted in half of the unilateral lung. That is to say, the destroyed lung should be limited in no more than two lobes in the right lung and one lobe in the left [2] if the lung fissure can be identified. The advantage of that is to ensure pneumonectomy successfully performed. Also, it increases the internal validity by reducing the impact from a mediastinal shift or lung herniation which complicates the analysis of oxygenation. Finally, this also reduces the perioperative complications and the time required for the compensation of pulmonary function by the remaining lobes. 3. The ages of the participants are limited from 18 to 80 years old; 4. Participants are selected based on CT scan with findings of the destroyed lung, despite the causes, stages of diseases, or whether they have received treatment; 5. PaO2 < 90 mmHg in screening test.
Exclusion criteria
Exclusion criteria: 1. Females with pregnancy or breast breeding are excluded. 2. Acute heart dysfunction (BNP > 2000). 3. Acute coronary syndrome. 4. Blood clotting diseases including thrombosis and stroke. 5. Circulation problems which prevent blood gas drawing in the radial artery. 6. Renal failure or those with dialysis. 7. Severe anaemia (haemoglobin < 6 g/dL).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Partial Pressure of Oxygen; | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline Arterial Saturation of Oxygen;Arterial Saturation of Oxygen (6MWT);FEV1;Resolved Symptoms; | — |
Countries
China
Contacts
Public ContactHui-Long Ye
President of the Third Hospital of Zhangzhou
Outcome results
None listed