Prophylactic antibiotic treatment during the perioperative period of endoscopic submucosal dissection of the digestive tract: a randomized controlled study

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100042115

Enrollment

Unknown

Registered

2021-01-14

Start date

2021-01-18

Completion date

Unknown

Last updated

2021-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endoscopic submucosal dissection

Interventions

Experimental group:Prophylactic antibiotic treatment for 3 days

control group:Placebo treatment for 3 days

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Normal temperature before endoscopic submucosal dissection ; 2.Have indications for endoscopic submucosal dissection, no absolute contraindications; 3.Aged 18 to 80 years, no gender limit; 4.Signed informed consent.

Exclusion criteria

Exclusion criteria: 1.Obvious perforation, aspiration, massive bleeding during and after operation; 2.Endoscopic submucosal dissection failed; 3.Antibiotic treatment 1 week before operation; 4.Have other active infections; 5.Suffering from immunocompromised disease; 6.In the stage of immunosuppressive therapy; 7.Allergic to the antibiotics in the study; 8.Pregnant and lactating women; 9.Participating in other clinical trials.

Design outcomes

Primary

Measure	Time frame
Clinical adverse events after endoscopic submucosal dissection;Inflammation index;	—

Secondary

Measure	Time frame
Blood culture;Wound healing;	—

Countries

China

Contacts

Public ContactMei Liu

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

fliumei@126.com+86 18627714881

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026