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Is a split-dose intravenous dexamethasone regimen superior to a single high dose in reducing pain and improving function after joint arthroplasty?

Is a split-dose intravenous dexamethasone regimen superior to a single high dose in reducing pain and improving function after joint arthroplasty?

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100042077
Enrollment
Unknown
Registered
2021-01-13
Start date
2021-01-12
Completion date
Unknown
Last updated
2021-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

joint arthroplasty

Interventions

Split-dose group :Split-dose
Single high dose group:Single high dose group
Normal saline group:Normal saline group

Sponsors

Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: We enrolled consecutive patients aged 18 years and older who were diagnosed with joint osteoarthritis and planned to undergo selective, unilateral, primary joint replacement.

Exclusion criteria

Exclusion criteria: Exclusion criteria were contraindication to using any of the study drugs, history of alcohol or substance abuse, cognitive impairment, severe liver and kidney function deficiency, and the presence of rheumatoid disease, systemic lupus erythematous, or ankylosing spondylitis.

Design outcomes

Secondary

MeasureTime frame
CRP?;IL-6;PONV;Use of analgesic and antiemetic rescue;ROM;LOS;—

Primary

MeasureTime frame
VAS at rest;VAS at activity;—

Countries

China

Contacts

Public ContactFeng Shuo

Affiliated Hospital of Xuzhou Medical University

xzfs0561@163.com+86 18552880088

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026