Safety and Efficacy of Transnasal Humidified Rapid Insufflation Ventilatory Exchange with Different Oxygen Concentration for Laser Laryngologic Surgery: a Patient-Blind Randomized Controlled Trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100042064

Enrollment

Unknown

Registered

2021-01-13

Start date

2021-01-18

Completion date

Unknown

Last updated

2021-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vocal cord web/lesion/tumor and other diseases need to be treated with laser laryngologic surgery

Interventions

THRIVE1.0-0.3:100% oxygen

THRIVE0.3:30% oxygen all time

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 60 years; 2. ASA I~II; 3. Planed for laser larygologic surgery under general anesthesia; 4. Anticipated surgery duration shorter than 20 min.

Exclusion criteria

Exclusion criteria: 1. Severe upper airway obstruction; 2. known difficult mask ventilation or difficult intubation; 3. skull base fracture or other defects; 4. severe cardiovascular or cerebrovascular diseases; 5. upper respiratory tract infection within 2 weeks; 6. bronchiectasia or other pulmonary diseases; 7. neuromuscular disorders; 8. obesity with BMI above 35; 9. severe or poorly controlled gastroesophageal reflux disease; 10. pregnancy; 11. allergy to any agent used in the study; 12. patient refuse to participate in the study.

Design outcomes

Primary

Measure	Time frame
Patient Proportion with Sp02 below 95% intraoperatively;	—

Secondary

Measure	Time frame
times of hypoxia;duration of hypoxia;surgical field laser sparks;	—

Countries

China

Contacts

Public ContactLi Wenxian

Eye & ENT Hospital, Fudan University

liwenxian@eentanesthesia.com+86 13917426838

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026