colorectal cancer
Conditions
Interventions
QLB1:lateral QL block
QBL3: anterior QL block
QBL2: posterior QL block
TAP:TAP block
C:general anesthesia without nerve block
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Aged 18-75 years; Elective surgery for colorectal cancer under general anesthesia; American Society of Anesthesiologists (ASA) physical status I/II/III; Be willing to participate in this study and sign written informed consent.
Exclusion criteria
Exclusion criteria: (1) With infection disease; (2) severe puncture site infection or structure in ultrasound is unclear; (3) history of coagulation dysfunction or hemorrhagic disease; (4) be allergic to local anesthetics (5) psychiatric and neurological disorders (6) severe liver dysfunction (>= child-plugh level 3),or severe renal dysfunction (serum creatinine >= 177µmol/L); (7) history of immune disease or usage of immunosuppressive drugs; (8) have a history of splenic disease and/or splenectomy; (9) with distant organs metastasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the dose of propofol and opioids during surgery;intraoperative hemodynamic parameters;VAS scores for rest and movement;the number of compressions of analgesic pump and the dose of rescue analgesics within 48 h after surgery;plasma levels of norepinephrine, adrenaline, cortisol and TNF-a, INF-?, IL-12, IL-4, IL-10;tumor recurrence and metastasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| awake time, extubation time, agitation score during recovery period;incidence of injection pain;Recovery quality score at 24h after surgery;the recovery time of gastrointestinal function, length of stay;Postoperative complications; | — |
Countries
China
Contacts
Public ContactZhao Weihong
The First Affiliated Hospital of Nanchang University
Outcome results
None listed