Patients with abdominal and orthopedic postoperative pain
Conditions
Interventions
experimental group:The first intravenous infusion of ibuprofen injection of 0.4g or 0.8mg was started 30min before the end of the operation. Ibuprofen was added to 200ml 0.9% sodium chloride injection
control group:Placebo
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years old men or women; 2. Endoscopic surgery with incision (incision >= 5 cm) and abdominal opening (gallbladder) were performed under general anesthesia at the selected date; General surgery on the capsule, intestine or lower abdomen) or orthopedic surgery, and is expected to require 24 hours postoperatively. Patients with above morphine analgesia; 3. No venous infusion disorder; 4. ASA grade I or II patients; 5. The expected observation and treatment time in hospital or hospital >=24h; 6. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Body weight =140mmHg or diastolic blood pressure >=90 mmHg); 7) Patients who have used non-steroidal anti-inflammatory drugs within 12 hours; 8) Patients with abnormal liver and renal function [SGPT (ALT) or SGOT (AST) were higher than the normal value Limit of 1.5 times; Creatinine is more than 1.5 times the upper limit of normal value or is receiving dialysis treatment within 28 days prior to surgery]; 9) Patients who have used other analgesics, muscle relaxants or sedatives within 24 hours before surgery; 10) Patients with prior dependence on narcotic drugs or tolerance to opioids; 11) Patients who participated in other clinical studies within 3 months before surgery; 12) Patients with other conditions that the researcher considers inappropriate to participate in.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total morphine dosage 24h after operation; | — |
Countries
China
Contacts
Public ContactLiu Jin
West China Hospital, Sichuan University
Outcome results
None listed