Study on the pathogenesis of congenital cochlear nerve dysplasia

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100042034

Enrollment

Unknown

Registered

2021-01-12

Start date

2020-06-01

Completion date

Unknown

Last updated

2021-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ear Diseases

Interventions

Cochlear nerve dysplasia group:Nil

Healthy control group:Nil

Eligibility

Sex/Gender

All

Age

No minimum to 80 Years

Inclusion criteria

Inclusion criteria: In the experimental group: 1. Oblique sagittal magnetic resonance imaging of internal auditory canal confirmed that the cochlear nerve branches on both sides or one side of the patient were missing or small; 2. Pure tone hearing threshold ASSR ABR examination showed severe or very severe hearing loss; 3. The immediate family members (biological father, mother, grandparents and maternal grandparents) of the patients who met the conditions of 1. And 2. Control group: exon sequencing database of healthy people.

Exclusion criteria

Exclusion criteria: 1. Patients with other malformations of inner or middle ear; 2. Patients with other nervous system diseases; 3. Merge other diseases that will affect the results of this study and the health of patients.

Design outcomes

Primary

Measure	Time frame
Whole exon sequencing of genomic DNA;	—

Countries

China

Contacts

Public ContactDongdong Ren

Ophthalmology and Otolaryngology Hospital Affiliated to Fudan University

dongdong_ren@163.com+86 13801913332

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026