Donor-derived infection
Conditions
Interventions
Donor group:Collect blood, urine, sputum and BALF samples
Liver recipient group:Collect blood, urine, abdominal drainage and organ preservation fluid samples
Kidney recipient group:Collect blood, urine, abdominal drainage and organ preservation fluid samples
Sponsors
Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: There are 20 donors 1. Subjects older than 18 years old; 2. The brain death patients who are waiting for organ donation in our department should meet the criteria of 2010 American Academy of Neurology (AAN) for brain death: deep coma, disappearance of brainstem reflex and no spontaneous breathing should be met, and EEG and transcranial Doppler ultrasound should be confirmed twice in a row; 3. Informed consent of patients' family members has been obtained. 20 liver transplant recipients: each donor corresponds to one liver transplant recipient, which is judged by the clinical standard of organ transplantation clinicians. 20-40 cases of renal transplant recipients: each donor corresponds to 1-2 renal transplant recipients, which are judged by the clinical standard of organ transplantation clinicians.
Exclusion criteria
Exclusion criteria: Donor exclusion criteria: 1. Untreated pneumonia, syphilis, bacterial or fungal sepsis, bacterial meningitis, parasitic infection, etc; 2. Active infection, such as tuberculosis, endemic mycosis, viremia, viral hepatitis (hepatitis B and hepatitis C require informed consent), etc; 3. HTLV-1 / 2 infection and HIV infection. The exclusion criteria were as follows 1. Subjects who did not agree to keep body fluid samples; 2. Those recipients who were not treated surgically in our hospital.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90-day mortality;30-day mortality;Hospital mortality;ICU mortality;Possible DDI rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Operation duration;ICU length of stay;Hospital length of stay;Blood culture;Blood NGS results;Urine culture;Urine NGS results;Sputum culture;Sputum NGS results;Abdominal drainage culture;Abdominal drainage NGS result; | — |
Countries
China
Contacts
Public ContactCai Changjie
Department of Severe Medicine, the First Affiliated Hospital of Zhongshan University
Outcome results
None listed