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Study on the effect of berberine on the prevention of anastomotic scar formation after dacryocystorhinostomy

Study on the effect of berberine on the prevention of anastomotic scar formation after dacryocystorhinostomy

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100042026
Enrollment
Unknown
Registered
2021-01-12
Start date
2021-01-04
Completion date
Unknown
Last updated
2021-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstruction of lacrimal passage after dacryocystorhinostomy

Interventions

group 1:1.5mg/ml berberine solution
group 2:1.0mg/ml berberine solution
group 3:0.5mg/ml berberine solution

Sponsors

The Third Medical Center of PLA General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 59 Years

Inclusion criteria

Inclusion criteria: 1. Clear diagnosis of monocular patients with chronic dacryocystitis; 2. Patients who received dacryocystorhinostomy; 3. The patients who can achieve standardized review after operation were identified.

Exclusion criteria

Exclusion criteria: 1. Patients with chronic dacryocystitis after trauma; 2. Patients with history of epiphora and pyorrhea in the other eye; 3. Patients with scar constitution; 4. Patients with a history of connective tissue disease; 5. Patients with a history of severe allergic diseases; 6. The history of eye diseases included severe allergic conjunctivitis, recurrent iritis and glaucoma; 7. Patients who recently received intraocular injection of anti VEGF drugs; 8. Patients unwilling to participate in the study; 9. Patients who can't cooperate to complete the examination and investigation.

Design outcomes

Primary

MeasureTime frame
Munck tear-overflow score;The size, shape and scar degree of the anastomosis;

Countries

China

Contacts

Public ContactFang Bai

The Third Medical Center of PLA General Hospital

baifang@301hospital.com.cn+86 18618249879

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026