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Corneal cross-linking treatment of keratoconus by increasing the irradiation time of simK2 axial cross-linking to reduce corneal astigmatism

Clinical observation of corneal cross-linking by covering method in reducing keratoconus astigmatism

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100042008
Enrollment
Unknown
Registered
2021-01-12
Start date
2018-02-01
Completion date
Unknown
Last updated
2021-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus

Interventions

experimental group:Increasing simk2 axial irradiation
control group:Conventional irradiation

Sponsors

Ophthalmic Hospital affiliated to Shandong First Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
14 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients with keratoconus diagnosed in our hospital and treated with epithelial CXL. 2. All patients were in the progressive stage of primary keratoconus, and there was no obvious scar formation in the center of cornea; 3. Those patients who have no other eye diseases affecting vision; 4. Patients who are willing and able to follow up.

Exclusion criteria

Exclusion criteria: 1. Subjects with acute eye infection or other active eye diseases; 2. For those who stopped wearing hard contact lenses for less than 4 weeks before treatment, soft contact lenses stopped wearing for less than 2 weeks; 3. Subjects with drug allergy during treatment; 4. Patients with diabetes, hypertension, cardiovascular disease and other systemic diseases; 5. Women who are pregnant or lactating or are about to get pregnant; 6. Patients who cannot understand or cooperate with this study.

Design outcomes

Primary

MeasureTime frame
Corneal topography;Subjective optometry;Naked eyesight;

Secondary

MeasureTime frame
Corneal endothelium;Postoperative complications;

Countries

china

Contacts

Public ContactTing Wang

Ophthalmic Hospital affiliated to Shandong First Medical University

wt-ting@163.com+86 13869182795

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026