Thyroid
Conditions
Interventions
experimental group:LT4
control group:Placebo
Sponsors
Peking University First Hospitai
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women of childbearing age, subjects aged 18-45, natural pregnancy, singleton pregnancy; 2. Subjects with TSH between 2.5miu/l-ulrr within 8 weeks of gestation had normal FT4 and negative TPOAb; 3. Subjects who signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects with a history of recurrent miscarriage ( >= 3 times); 2. Subjects of assisted reproduction (artificial insemination, test tube baby); 3. Patients with diseases that seriously affect adverse pregnancy outcomes, including hypertension, diabetes, heart disease, liver and kidney dysfunction, etc; 4. Patients with important organ failure; 5. Patients with autoimmune diseases other than autoimmune thyroid diseases; 6. Patients with thyroid diseases (including hyperthyroidism, thyroid cancer, thyroid amyloidosis and other extensive lesions in the thyroid, subacute thyroiditis, iodine deficiency endemic goiter, thyroid ultrasound showed diffuse thyroid lesions after thyroidectomy or 131I treatment, etc.); 7. Screening of patients with thyroid related drugs (lithium carbonate, thiourea, sulfonamides, sodium p-aminosalicylate, potassium perchlorate, Baotaisong, thiobicarbonate, tyrosine kinase inhibitors, etc.) and drugs affecting thyroid function test (glucocorticoid, metoclopramide, propranolol, amiodarone, sodium valproate, etc.); 8. Patients with secondary and central hypothyroidism (pituitary tumor, surgery, radiotherapy, lymphocytic hypophysitis, etc.); 9. Patients with L-T4 allergy; 10. Other clinicians judged that they were not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fetus loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Delivery situation;Pregnancy week;Miscarriage treatment during pregnancy;Pregnany complications and adverse outcomes;Fetal growth and development (ultrasound);Apgar (1min, 5min);Whether the newborn is admitted to ICU;Birth length;Birth weight; | — |
Countries
China
Contacts
Public ContactGao Ying
Peking University First Hospital
Outcome results
None listed