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Effect of Linaclotide on bowel preparation for colonoscopy: a multicenter prospective randomized controlled trial

Effect of Linaclotide on bowel preparation for colonoscopy: a multicenter prospective randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100041992
Enrollment
Unknown
Registered
2021-01-11
Start date
2021-02-01
Completion date
Unknown
Last updated
2021-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bowel preparation

Interventions

Linaclotide+2L PEG:Linaclotide+2L PEG

Sponsors

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years; 2. Colonoscopy as planned; 3. Informed consent with signature and date; 4. Promise to abide by the research procedures and cooperate with the implementation of the whole process research.

Exclusion criteria

Exclusion criteria: 1. Severe heart failure (NYC grade III or IV); 2. Recent acute myocardial infarction or unstable angina pectoris; 3. Uncontrolled hypertension; 4. Chronic kidney disease; 5. Suspected intestinal obstruction or perforation; 6. Before intestinal resection; 7. Gastroparesis; 8. Diarrhea more than 3 times a day; 9. Cirrhosis or ascites: 10. Pregnant or lactating women; 11. Those who have mental illness and cannot cooperate with the examination; 12. Allergic to bowel preparation drugs.

Design outcomes

Primary

MeasureTime frame
Bowel preparation cleanliness score (Ottawa score);

Secondary

MeasureTime frame
Feeling score of patients during colonoscopy;Feeling score of patients during bowel preparation;Detection rate of intestinal polyps;Adenoma detection rate;Success rate of terminal ileal intubation;Time to the ileocecal part;

Countries

China

Contacts

Public ContactXiaohua Hou

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

houxh@hust.edu.cn+86 27-85726057

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026