Carbapenem-resistant bacterial infection in patients with agranulocytosis and fever after chemotherapy for hematological malignancies
Conditions
Interventions
case series:Nil
Sponsors
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or non-pregnant non-lactating female patients, aged >= 18 years; 2. Patients with agranulocytosis with fever after chemotherapy for hematological malignancies according to the 2017 WHO CRE active screening criteria (except non-hematologic malignancies such as aplastic anemia, etc.); 3. Known to have carried CRE or had close contact with CRE carriers in the past 12 months; 4. Multiple (two or more) microbial cultures during the study in the same patient suggest carbapenem resistance for patients with positive gram-negative bacteria, the medical records at the first infection were extracted; 5. Microbial culture of different sites in the same patient suggests that carbapenem-resistant negative bacteria are positive, when first detected of medical records; 6. Patients with clear infection or signs of infection at admission; 7. Be able to receive relevant examinations at the time points required by the protocol; 8. Signed written informed consent, and can comply with the relevant procedures specified in the protocol.
Exclusion criteria
Exclusion criteria: 1. Patients with non-hematological malignancies such as aplastic anemia and hemolytic anemia; 2. Uncontrolled intercurrent illness including but not limited to: HIV-infected (HIV antibody positive); Severe hepatic or renal failure; Severe respiratory failure on ventilator; High medical risk and/or uncertainty in survival evaluation; 3. Female subjects who are pregnant or lactating. 4. Other conditions that the investigator believes are not suitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactMei Hong
Union Hospital, Tongji Medical College of HUST
Outcome results
None listed