Migraine
Conditions
Interventions
Paroxysmal migraine and chronic migraine:No intervention
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients are between 18 to 60 years old; 2. Migraineurs is diagnosed according to ICHD-3; 3. Patients have normal structure and function of right heart; 4. Female patients are not in pregnancy or lactation; 5. Patients are willing to take the examinations of magnetic resonance venography (MRV) and contrast-enhanced ultrasound (CEUS) and noninvasive intracranial pressure monitoring based on flash visual evoked potentials (FVEP); 6. Patients have signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients suffer from other primary or secondary headache; 2. Patients suffer from any congenital or acquired intracranial abnormality, venous thrombosis, encephalitis, intracranial tumor or previous brain surgery; 3. Patients suffer from autoimmune diseases or other serious physical diseases; 4. Patients suffer from hemodynamic abnormal, such as anemia, hypertension, hyperlipidemia, hyperthyroidism, diabetes and so on. 5. Patients suffer from other chronic disabling diseases, such as dementia, osteoarthritis, serious mental disorder, quadriplegia, congenital malformation, COPD and so on. 6. Patients don't want or cant complete examinations; 7. Patients don't complete questionnaires or communicate normally; 8. Patients have contraindications to MRV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral circulation time;Cerebral perfusion pressure;The structure of cerebral venous sinus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intracranial pressure;Cerebral blood flow;cerebral blood volume;Internal diameters of bilateral internal jugular;Minimum velocities of bilateral internal jugular during free breath;Maximum velocities of bilateral internal jugular during free breath;Maximum velocities of bilateral internal jugular with Valsalva maneuver;Maximum backflow time of bilateral internal jugular with Valsalva maneuver;Internal diameters of bilateral internal carotid arteries;Outflow volume of bilateral internal carotid arteries;Maximum velocities of bilateral internal carotid arteries;Minimum velocities of bilateral internal carotid arteries;Resistance index of bilateral internal carotid arteries;Internal diameters of bilateral vertebral arteries;Outflow volume of bilateral vertebral arteries;Maximum velocities of bilateral vertebral arteries;Minimum velocities of bilateral vertebral arteries;Resistance index of bilateral vertebral arteries;NRS;HIT-6;MIDAS;HAMD;HAMA; | — |
Countries
China
Contacts
Public ContactGuogang Luo
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed