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Effect of pelvic radiotherapy on vaginal microflora in patients with cervical carcinoma: an observational clinical trial

Effect of pelvic radiotherapy on vaginal microflora in patients with cervical carcinoma: an observational clinical trial

Status
Recruiting
Phases
Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100041930
Enrollment
Unknown
Registered
2021-01-10
Start date
2021-01-07
Completion date
Unknown
Last updated
2021-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical carcinoma

Interventions

Sponsors

Guangdong Provincial Hospital of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.The result of pathologically confirmed cervical carcinoma (FIGO: a stage of IIB-IVA) and did not undergo a hysterectomy. 2.Receive pelvic radiotherapy. 3.No serious organic diseases including heart, lung, liver and kidney. 4.KPS score >= 60. 5.Aware of the condition and volunteered to participate in this study.

Exclusion criteria

Exclusion criteria: 1.Patients combined with other reproductive system diseases. 2.Patients with other malignant tumors before entering the group. 3.Patients concomitant immune system disease or other infectious disease. 4.Patients being treated with antibiotics. 5.Patients with mental disorders or Alzheimer's disease who are unable to communicate with medical staff.

Design outcomes

Primary

MeasureTime frame
Diversity, richness and change index of main bacteria before and after pelvic radiotherapy;Symptoms associated with radioactive vaginal injury in patients undergoing pelvic radiotherapy;

Secondary

MeasureTime frame
Change index of lactobacillus before and after pelvic radiotherapy;Incidence of radioactive vaginal injury after pelvic radiotherapy;

Countries

China

Contacts

Public ContactGao Lei

Guangzhou University of Chinese Medicine

gzgaolei@126.com+86 15920999579

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026