Rheumatoid arthritis
Conditions
Interventions
Sponsors
Yunnan Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. According to the ACR rheumatoid arthritis diagnostic criteria of 1987 and TCM diagnostic criteria of wind cold dampness syndrome; 2. Patients with RA disease activity whose DAS28 score is greater than 2.6; 3. Patients who had taken glucocorticoids (prednisone acetate tablets >= 20mg/d or equivalent dose if DAS28 score >= 5.1; Prednisone Acetate Tablets >= 10mg/d or equivalent dose if DAS28 score < 5.1); 4. Aged from 18 to 65 years, male or female; 5. Those who voluntarily participate in the trial and agree to enter the clinical study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. There was a history of severe respiratory (including pulmonary interstitial fibrosis), blood circulation disorder, digestive, endocrine, urinary system diseases and malignant tumor before the trial; 2. Patients with bleeding tendency, active gastrointestinal disease and recent history of surgery; 3. There was infection that could not be controlled by antibiotics, and there was a history of severe infection or opportunistic infection 2 months before the trial; 4. Biological agents have been used in recent one month; 5. Pregnant and lactating women; 6. Patients participating in other clinical trials; 7. Allergic constitution (allergic to traditional Chinese medicine, hormone and other experimental drugs); 8. Mental patients; 9. Suspected or true history of alcohol or drug abuse, or other diseases that reduce or complicate the possibility of enrollment, such as frequent changes in working environment, are likely to cause loss of follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Joint swelling number;Number of joint tenderness;DAS28 score;Hormone withdrawal; | — |
Secondary
| Measure | Time frame |
|---|---|
| Curative effect of TCM diseases;TCM syndromes are equally divided;VAS score for the degree of pain assessed by the patient;The patient assessed the overall condition of the disease VAS score;The overall condition VAS score for the disease was assessed by the researchers;Health Assessment Questionnaire (HAQ);ACR20 standard than;cortisol;Corticotropin;Lymphocyte subsets;cytokines;Erythrocyte sedimentation rate;C-reactive protein;Hypersensitive C-reactive protein; | — |
Countries
China
Contacts
Public ContactWu Yang
Yunnan University of Traditional Chinese Medicine
Outcome results
None listed