Schizophrenia
Conditions
Interventions
Intervention group-Schizophrenia:Drug therapy combined with rTMS intervention
Control group-Schizophrenia:Drug therapy
Intervention group-Depression:Drug therapy combined with rTMS intervention
Control group-Depression:Drug therapy
Sponsors
The First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Diagnosed by a clinical psychiatrist and meeting the DSM-V diagnostic criteria for schizophrenia and depression; (2) In the positive and negative symptoms scale (PANSS) for schizophrenic patients, there were at least 1 > 3 points and P3 hallucination > 3 points in the 4 items (degree of paranoia) of P1 delusion, P5 exaggeration, P6 paranoia/murder and G9 abnormal thinking, which were classified as positive symptoms group;Negative symptom score >18 points, classified as negative symptom group; (3) Hamilton depression scale (hamd-17) total score > 18 for patients with depression; (4) According to the patient's condition, amesulfapidyl tablets and Venlafaxine hydrochloride sustained-release capsules should be selected during the treatment of schizophrenia and depression; (5) Aged 18-50 years, Han nationality, right-handed; (6) Volunteer to participate in the experiment and cooperate, and give informed consent by myself or family members;(7) Education above junior high school level; (8) Onset or course of disease less than 3 years; (9) Antipsychotic drugs were not used in at least 5 half-lives of the drugs before enrollment, and the drug treatment dose was stable at a certain level; (10) At least 4 weeks in the stable period of disease.
Exclusion criteria
Exclusion criteria: (1) Those with brain organic diseases and serious physical diseases such as endocrine system; (2) Intestinal organic lesions were confirmed by relevant auxiliary examinations; (3) women during pregnancy and breastfeeding; (4) A history of alcohol and drug dependence; (5) A history of manic or hypomanic episodes; (6) Depressive episodes accompanied by psychotic symptoms; (7) Electroconvulsive therapy; (8) Persons with impulsive tendencies such as severe suicide, self-injury or wounding; (9) Did not take drugs such as swelling agent, antidiarrid, antibiotic, spasmodic, probiotics and so on within one month; (10) BMI greater than or equal to 32.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PNASS;HAMD;MCCB; | — |
Countries
China
Contacts
Public ContactWang Huaning
The First Affiliated Hospital of Air Force Medical University
Outcome results
None listed