Acute pain
Conditions
Interventions
Control group:Normal saline
Experiment group:Esmketamine hydrochloride
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Aged over 65 years old and the gender is not limited; 2) Body mass index (BMI) between 18.5 ~ 25 kg / m2, ASA I ~ III grade; 3) Patients undergoing laparoscopic cholecystectomy and operation time last about 1 hour; 4) Hospital stay more than 48 hours.
Exclusion criteria
Exclusion criteria: 1) Patients with mental history or with antipsychotic drugs; 2) Patients with abuse of narcotic analgesics or sedatives, such as ketamine, patients with alcohol abuse; 3) Patients who are allergic to propofol, opioids, esmketamine and other narcotic drugs or have contraindications; 4) Patients with vision loss or intraocular pressure can not be increased; 5) Patients using drugs (such as aminophylline or theophylline) that affect the evaluation of efficacy and safety were used; 6) Patients using drugs that affect the liver and kidney metabolism of esmketamine, such as liver enzyme inhibitor chlorpromazine, etc; 7) Patients with severe decompensation of liver and kidney function; 8) Patients with severe risk of elevated blood pressure or intracranial pressure, poorly controlled or untreated hypertension (arterial hypertension, resting systolic / diastolic blood pressure more than 180 / 100mmhg); 9) Patients with hyperthyroidism; 10) Patients with unstable angina pectoris or myocardial infarction occurred in the past 6 months; previous severe angina pectoris; congestive heart failure; 11) The researchers judged that the subjects, including but not limited to the patients with important organ dysfunction and / or severe systemic diseases, were not suitable to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosage of analgesics; | — |
Secondary
| Measure | Time frame |
|---|---|
| visual analogue scale; | — |
Countries
China
Contacts
Public ContactXiangrui Wang
Shanghai East Hospital
Outcome results
None listed