Alzheimer's disease
Conditions
Interventions
control group:Sham transcranial alternating current stimulation
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Male
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. National Stroke Institute for Neurological Speech Disorders and the Association for AD-related Disorders (NINCDS-ADRDA); 2 The diagnostic criteria for AD in the Chinese Classification and Diagnostic Criteria of Mental Disorders (CCMD-3); 3. Age >= 45 years old and <= 85 years old, regardless of gender; 4. Assessment of AD core symptoms: patients or informed persons reported progressive recent memory decline over 6 months; 5. Amyloid PET imaging, increased tracer retention; 6. Retained partial comprehension ability, manual ability, vision, hearing ability and verbal communication ability; 7. Right-handed, primary school education or above; 8.Subjects and their legal guardians (if necessary) understand and agree to participate in the study and sign the informed consent; 9. Patients and their family members understand the trial process and are willing to actively cooperate with the trial development and examination.
Exclusion criteria
Exclusion criteria: 1. Patients with serious primary or secondary diseases, such as severe hematopoietic system diseases of liver and kidney, severe cardiopulmonary insufficiency or infectious diseases, and malignant tumors; 2. Other types of dementia: such as vascular dementia and Lewy body dementia caused by various cerebrovascular diseases; 3. Severe dementia patients: those who resist or cannot cooperate; 4. High degree of convulsion;People with obvious emotional or mental disorders; 5. Patients with skull defect, pacemaker, or metal implant are not suitable for MRI and TACS examination; 6. Alcoholics and drug addicts; 7. Pregnant or lactating women; 8. Uncooperative subjects: those who cannot understand and refuse to sign the informed consent for the clinical trial and normal healthy subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG;Functional near-infrared spectroscopy;eyemovement;fMRI;MMSE;MoCA; | — |
Countries
China
Contacts
Public ContactYuanli Li
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed