Hepatic ischemia reperfusion injury
Conditions
Interventions
experimental group:Pretreatment with glutathione and vitamin C
control group:Pretreatment with physiological saline
Sponsors
Taizhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Preoperative diagnosis was liver malignant tumor, liver benign tumor, intrahepatic bile duct stones, liver trauma, liver abscess, hepatic echinococcosis, etc., with surgical indications (2) The American society of anesthesiologists (ASA) classification for I/ II level (3) Subtotal liver resection is expected; According to the Quinade liver segmentation method, the resection range was not less than one liver segment. During the operation, the bleeding was controlled by the hepatic portal blood flow blocking method (Pringle method). The maximum time of each block was 15min, and the bleeding could be blocked again after the intermittent release of 5min.
Exclusion criteria
Exclusion criteria: (1) Severe underlying disease or organ failure or infection; (2) Anticoagulants or antiplatelet agents have been used before surgery; (3) Use of hormones, statins, pioglitazone, dextrometomidine and other drugs that have been reported to have similar effects of target drugs within one week before surgery; (4) Other blood flow blocking methods were also applied during the operation; (5) Due to various reasons, the acquisition of observation indicators is not perfect or surgery is not performed as planned.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glutamic-pyruvic transaminase;glutamic oxalacetic transaminase;total bilirubin;superoxide dismutase;catalase;White blood cell count;Neutrophil count;C-reactive protein;platelet;prothrombin time;Hospital stay; | — |
Countries
China
Contacts
Public ContactChanghe Zhang
Taizhou People's Hospital
Outcome results
None listed